General Cell Based Assays
Eurofins Discoverx cAMP Hunter™ Human GPR84 Gi Cell-Based Assay Kit (CHO-K1)
The cAMP Hunter™ Human GPR84 Gi Stable Cell Line Assay (CHO-K1) contains a stable clonal cell line used to measure GPR84 (GPCR) activity via decreased levels of intracellular cAMP. This is a complete kit that includes the cell vials and all required reagents needed for cell culture and running the assay.
Eurofins Discoverx PathHunter Mouse Insulin Receptor A (INSRa) Functional Kinase Cell-Based Assay Kit (U2OS)
The PathHunter Mouse Insulin Receptor A (INSRa) Stable Cell Line Functional Kinase Assay (U2OS) measures INSRa receptor tyrosine kinase activity via ligand-induced SH2 domain protein recruitment. This is a complete kit that includes the cell vials and all required reagents needed for cell culture and running the assay.
Eurofins Discoverx PathHunter eXpress ADRA1B CHO-K1 β-Arrestin GPCR Assay, 10-Plate Kit. (93-0274E2CP0L)
The PathHunter ADRA1B eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. epinephrine and norepinephrine) based activation of ADRA1B GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged ADRA1B and EA-tagged β-Arrestin-2. Activation of ADRA1B stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Discovery Life Sciences Gentest Monkey Hep Rhesu
Gentest Monkey Hepatocytes Rhesus Cryopreserved Suspension
Eurofins Discoverx cAMP Hunter eXpress ADCYAP1R1 (PAC1) CHO-K1 GPCR Assay, 10pl Kit. (95-0064E2CP2L)
The cAMP Hunter ADCYAP1R1 (PAC1) eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. PACAP) based activation of ADCYAP1R1 GPCR activity via detection of increasing levels of intracellular cAMP. This product uses EFC technology. The cells overexpress wild type ADCYAP1R1, a naturally Gs coupled GPCR. Upon activation of ADCYAP1R1, the increase in levels of intracellular cAMP leads to an increased signal from EFC when the cAMP detection kit is applied. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx PathHunter Human ADRA2C β-Arrestin Cell-Based Assay Kit (CHO-K1)
The PathHunter Human ADRA2C β-Arrestin Stable Cell Line Assay (CHO-K1) contains a stable clonal cell line used to measure ADRA2C (GPCR) activity via recruitment of β-Arrestin2. This is a complete kit that includes the cell vials and all required reagents needed for cell culture and running the assay.
Abcam Cerivastatin sodium, HMG-CoA reductase inhibitor, 5MG
MW 481.5 Da, Purity >98%. Potent HMG-CoA reductase inhibitor (Ki = 13 nM). Shows higher potency than Lovastatin (ab120614). Enantiomerically pure pyridine derivative. Reduces plasma cholesterol levels in vivo. Orally active.
The product is subject to the following: Abcam Restricted Use Statement
Eurofins Discoverx PathHunter Human GLP-2 (GLP-2 Receptor) Activated GPCR Internalization Cell-Based Assay Kit (U2OS)
The PathHunter Human GLP-2 (GLP2R) Stable Cell Line Activated GPCR Internalization Assay (U2OS) contains a stable clonal cell line used to measure GLP2R (GPCR) internalization via early-endosome localization. This is a complete kit that includes the cell vials and all required reagents needed for cell culture and running the assay.
Eurofins Discoverx cAMP Hunter™ Human FPR1 Gi Cell-Based Assay Kit (CHO-K1)
The cAMP Hunter™ Human FPR1 Gi Stable Cell Line Assay (CHO-K1) contains a stable clonal cell line used to measure FPR1 (GPCR) activity via decreased levels of intracellular cAMP. This is a complete kit that includes the cell vials and all required reagents needed for cell culture and running the assay.
Eurofins Discoverx PathHunter eXpress mCCR6 CHO-K1 β-Arrestin GPCR Assay, 10-Plate Kit. (93-0694E2MCP2L)
The PathHunter mCCR6 eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. CCL20/MIP-3α) based activation of mCCR6 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged mCCR6 and EA-tagged β-Arrestin-2. Activation of mCCR6 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. Please note that this product expresses the Mouse version of this protein. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
AURORA BIOLABS LLC Cov-19 NP Mouse Binding Assay, 384 rxn
SARS-CoV-2 Nucleocapsid protein (NP) is one of the core components of SARS-CoV-2 virus. It forms a complex with viral genomic RNA in a helical symmetrical structure and plays a key role in the process of virus replication and assembly. Since NP is abundantly expressed during infection, it can be used as an important diagnostic marker for COVID-19 and also can be used as a potential drug target or developing vaccines. Terbium-labeled anti-Tag5 antibody serves as fluorescence donor, that binds to the Tag5-NP. If a test mouse antibody binds to NP, fluorescence- labeled anti-mouse antibody (fluorescence acceptor) will be brought in close proximity with the fluorescence donor. Excitation of Terbium (340 nm) generates fluorescence resonance energy transfer (FRET) to the fluorescence-labeled acceptor, which consequently fluoresces at 665 nm (figure below). Thus, the test antibody binding to NP can be quantitively measured by calculation of the fluorescent ratio of 665 nm/620 nm.
Enzo Life Sciences MMP-1 Assay Buffer (20ml)
Formulation: Liquid. In 50mM HEPES, pH 7.5, 10mM CaCl2 and 0.05% Brij-35. Long Term Storage: Ambient.
Meso Scale Discovery U-PLEX Mouse KC/GRO ASY
The U-PLEX Mouse KC Assay K152VWK from Meso Scale Discovery is a multiplex immunoassay kit for measuring cytokines and chemokines in mouse samples It uses electrochemiluminescence detection to measure up to 10 analytes per well from a single sample The kit includes a 96-well plate detection antibodies calibrator solutions and buffers It requires 25 L of sample per well and can quantify IL-1 IL-2 IL-4 IL-5 IL-6 IL-10 IL-12p70 IFN- TNF- and KC/GRO in various biological fluids
Meso Scale Discovery R-PLEX Human P-Cadherin ASY
The R-Plex Human P-Cadherin Assay is a multiplex immunoassay kit that enables the simultaneous quantitative measurement of P-Cadherin in human serum plasma and cell culture supernatants It utilizes Meso Scale Discovery electrochemiluminescent detection technology and provides high sensitivity broad dynamic range and intra- and inter-assay precision This assay requires an MSD instrument and provides components for one 96-well plate including one standard curve comprised of eight points ranging from 3 2 pg/mL to 10 000 pg/mL P-Cadherin